P-369 Association of vascular endothelial growth factor gene polymorphisms with esophageal squamous cell cancer risk in North-West Indians: A case-control study

Vascular endothelial growth factor (VEGF) is a crucial regulator of physiological and pathological angiogenesis. Increased VEGF expression has been linked with inappropriate VEGF-induced angiogenesis in various disease pathologies including cancers. The aim present study was to investigate the role seven promoter polymorphisms [-417T/C (rs833062), -172C/A (rs59260042), -165C/T (rs79469752), -160C/T, -152G/A (rs13207351), -141A/C (rs28357093), -116G/A (rs1570360) esophageal squamous cell cancer risk North-West Indians. In this case-control study, DNA samples 199 (ESCC) patients 210 healthy controls from Punjab, India were screened for -417T/C, -172C/A, -165C/T, -152G/A, using Sanger sequencing. mean age 56.16±12.98 54.06 ±11.99 years respectively. 62.81% patients, diagnosed after 50 years. number female higher as compared male patients. Of ESCC 25 (12.56%) had stage I, 89 (44.72%) II, 51 (25.63%) III, 18 (9.05%) IV tumor. AA genotype A allele both significantly associated elevated total subjects well group. CT T VEGF-165C/T polymorphism reduced only Linkage disequilibrium observed between (D′ = 0.85, r2 0.73) VEGF-152G/A 0.93, 0.50) polymorphisms. Haplotype T-C-C-C-A-A-A increased From we concluded that VEGF-116 G/A group whereas -165 C/T Identification correlation their haplotypes particular therapy may be helpful better selection treatment.